{"id":20126,"date":"2020-11-13T10:14:25","date_gmt":"2020-11-13T09:14:25","guid":{"rendered":"https:\/\/www.generationsanstabac.org\/actualites\/linfluence-de-la-genetique-sur-le-tabagisme\/"},"modified":"2020-11-13T10:14:25","modified_gmt":"2020-11-13T09:14:25","slug":"linfluence-de-la-genetique-sur-le-tabagisme","status":"publish","type":"actualites","link":"https:\/\/www.generationsanstabac.org\/en\/actualites\/linfluence-de-la-genetique-sur-le-tabagisme\/","title":{"rendered":"The influence of genetics on smoking"},"content":{"rendered":"

A new study from Yale University reveals genetic markers that could predict which people are more likely to start smoking and quit smoking compared to others.<\/em><\/p>\n

The study, published in the journal Nature on October 20, was co-authored by Yale School of Medicine psychiatry professor Ke Xu and biostatistics doctoral student Boyang Li. The researchers identified 99 genetic variants linked to smoking initiation and 13 variants linked to smoking cessation. This research was funded by the U.S. Department of Veterans Affairs and was part of its Million Veteran Program.<\/p>\n

A study conducted on veterans<\/h2>\n

More than 825,000 veterans have participated in the program, which aims to understand how genetic and environmental factors affect individual health.<\/p>\n

Researchers Xu and Li compared the highly diverse genomes of these individuals. With this large cohort, they were able to access data collected over a long period of time on the patients' smoking histories. They then identified areas of genetic variation that may be linked to a patient's likelihood of smoking or not.<\/p>\n

The significance of this study lies in the fact that once certain genetic markers that increase an individual's likelihood of smoking are identified, it becomes possible to more effectively treat people with these risk factors in a more targeted manner.<\/p>\n

One factor among others<\/h2>\n

While the study focuses on how a person's genetics affect their smoking behavior, Dr. Xu clarified that genes aren't the only factor determining smoking prevalence or cessation. The genetic influence of smoking is thought to be approximately 40 to 50%, meaning other environmental factors (education or smoking-related policies such as taxes or regulations) play a role.<\/p>\n

Genetics therefore contributes significantly to the risk of smoking without being the sole determinant. Antonio Giraldez, chair of the university's genetics department, says the next step in this research is to replicate the study with another large cohort to refine the results.<\/p>\n

\u00a9Generation Without Tobacco<\/a><\/span><\/p>\n

\n

This brief is based on the Yale Daily News publication that ran alongside the study:<\/p>\n

FLORES Kaitlin, PROMAN Amre, Smoking and quitting may be genetic, new research indicates<\/em><\/a>s, www.yaledailynews.com (November 5, 2020, accessed November 12, 2020).<\/p>\n

DNF \u2013 For a Zero Tobacco World |<\/a><\/strong><\/span><\/p>","protected":false},"excerpt":{"rendered":"

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